Spindle-cell squamous carcinoma of the esophagus: a tumor with biphasic morphology

Conference · Sun Sep 01 04:00:00 EDT 1985 · AJR, Am. J. Roentgenol.; (United States)

OSTI ID:5178293

Agha, F P; Keren, D F

Spindle-cell squamous carcinoma of the esophagus is a rare malignant tumor. It is characterized by a large bulky mass in the middle third of the esophagus with a lobulated surface and local expansion of the esophagus. This lesion may be pedunculated and cause relatively little obstruction despite its bulk. The current view, based on ultrastructure and immunohistochemical evidence, has confirmed that the sarcomatous component of the squamous cell carcinoma originates from mesenchymal metaplasia of squamous cells. On the basis of this evidence and clinical behavior, it seems appropriate to consider carcinosarcoma and pseudosarcoma as equivalents and as variants of squamous cell carcinoma. Four patients with spindle-cell squamous carcinoma, an unusual subset of squamous carcinoma, are described, and the salient radiographic and pathologic features of this disorder's distinctive biphasic morphology are discussed.

• Research Organization: Univ. of Michigan Hospitals and Medical Center, Ann Arbor
• OSTI ID: 5178293
• Report Number(s): CONF-860416-
• Conference Information: Journal Name: AJR, Am. J. Roentgenol.; (United States) Journal Volume: 145:3
• Country of Publication: United States
• Language: English

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550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
BODY
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
HISTOLOGY
MEDICINE
MORPHOLOGY
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
TOMOGRAPHY