In vivo study of the radioprotective effect of diethyldithiocarbamate (DDC)

Journal Article · Tue Nov 01 04:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90416-9· OSTI ID:5176932

Evans, R G; Engel, C R; Wheatley, C L; Nielsen, J R; Ciborowski, L J

Experiments in vivo have extended our knowledge of the radioprotective properties of DDC and show that the LD/sub 50/30/ in mice is increased from 780 rad to approximately 1400 rad when non-toxic concentrations of DDC are present prior to the irradiation. When DDC is present during irradiation, the pattern of death of the mice is similar to that seen in the absence of the drug and is quite different from that seen in animals dying of a gastrointestinal syndrome (LD/sub 50/7/ approx. = 1700 rad). To confirm that the LD/sub 50/30/ data represent bone marrow protection by DDC, we performed bone marrow CFU/sub s/ assays with and without the presence of DDC, at the time of in vivo irradiation. The D/sub 0/ of the CFU/sub s/ is increased from 80 rad in the control animals to 120 rad in the animals that have been pretreated with DDC. In experiments using /sup 35/S-labelled DDC, the tissue distribution of the drug in tumor-bearing mice indicates a preferential uptake of DDC in kidney, lung and bone marrow compared to tumor tissue.

• Research Organization: Mayo Clinic and Mayo Foundation, Rochester, MN
• OSTI ID: 5176932
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:11; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CFU
CHELATING AGENTS
COLONY FORMATION
DATA
DAYS LIVING RADIOISOTOPES
DEDTC
DISEASES
DISTRIBUTION
DOSES
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEMATOPOIETIC SYSTEM
IN VIVO
INFORMATION
IONIZING RADIATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LETHAL DOSES
LETHAL RADIATION DOSE
LIGHT NUCLEI
LUNGS
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION DOSES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SPLEEN COLONY FORMATION
SULFUR 35
SULFUR ISOTOPES
TISSUE DISTRIBUTION
TISSUES
TUMOR CELLS
VERTEBRATES
X RADIATION