Autonomous thyroid nodules in adolescents: clinical characteristics and results of TRH testing

Journal Article · Mon Mar 01 00:00:00 EST 1982 · J. Pediatr.; (United States)

DOI:https://doi.org/10.1016/S0022-3476(82)80434-4· OSTI ID:5176641

Osburne, R C; Goren, E N; Bybee, D E; Johnsonbaugh, R E

Seven adolescents with autonomous thyroid nodules were evaluated over a three-year period. They had hyperfunctioning nodules on radionuclide scan which failed to suppress with exogenous administration of thyroid hormone. They were clinically euthyroid and had normal T4, free T4, and basal TSH values. However, as a group they had elevated total serum T3 concentrations, blunted TSH response to TRH, and accelerated closure of cranial sutures, all of which suggested subtle hyperthyroidism. These patients have been followed for one to five years. Four have undergone partial thyroidectomy because of persistent elevation in the serum T3 concentration or enlargement of the nodule. The clinical presentation and laboratory findings in this group are similar to those found in adults with autonomous nodules.

• Research Organization: Division of Endocrinology and Metabolism, National Naval Medical Center, Bethesda, MD
• OSTI ID: 5176641
• Journal Information: J. Pediatr.; (United States), Vol. 100:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ENDOCRINE DISEASES
DIAGNOSIS
IODINE ISOTOPES
RADIOISOTOPE SCANNING
THYROID
ADOLESCENTS
PATIENTS
TRH
AGE GROUPS
BODY
COUNTING TECHNIQUES
DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
ISOTOPES
ORGANS
PEPTIDE HORMONES
550601* - Medicine- Unsealed Radionuclides in Diagnostics