Effect of gamma-linolenic acid and dihomo-gamma-linolenic acid 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5172619

Ramchurren, N; Karmali, R A ^[1]

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1. Rutgers-the State Univ., New Brunswick, NJ (United States)

Gamma-linolenic acid (GLA) and its sequential metabolite, dihomogamma-linolenic acid (DHLA) have been reported to influence growth of neoplastic cells in culture. The pure forms of these fatty acids have not been tested in vivo. The authors have studied the effect of GLA and DHLA on mammary tumors induced by 7,12-dimethylbenz(a) anthracene (DMBA) (7.5 mg/rat) in female Sprague-Dawley rats. Rats received either 0.15 g of GLA or DHLA or corn oil (CO) orally, twice weekly for a period of 12 weeks. All three groups of rats were maintained on a diet containing 5% (w/w) corn oil as fat. Tumor incidence and multiplicity were recorded. The group receiving 0.15 g Co had higher tumor yields than those receiving GLA or DHLA. At the end of the experiment, tumor incidence was the lowest in the group receiving DHLA. Tumor multiplicity was consistently lowest with GLA. Fatty acid composition of mammary tissue and liver reflected that of fatty acid treatment. These results suggest that oral administration of GLA or DHLA retards the development of DMBA-induced mammary tumors in rats receiving a diet containing 5% (w/w) corn oil.

• OSTI ID: 5172619
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
CARCINOGENESIS
LINOLENIC ACID
BIOLOGICAL EFFECTS
MAMMARY GLANDS
EXPERIMENTAL NEOPLASMS
ORAL ADMINISTRATION
RATS
ANIMALS
AROMATICS
BODY
CARBOXYLIC ACIDS
CONDENSED AROMATICS
GLANDS
HYDROCARBONS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology