Assessment of risks to human reproduction and to development of the human conceptus from exposure to environmental substances

Conference · Mon Feb 01 04:00:00 EST 1982

OSTI ID:5171784

Galbraith, W M; Voytek, P; Ryon, M G

The Offices of Health Research and of Health and Environmental Assessment within the Office of Research and Development sponsored a conference to produce a technical document on the current status of risk assessment methodologies for teratogenic and other reproductive effects. The conference brought together scientists knowledgeable in reproductive biology and teratology to discuss techniques and concepts pertinent to developing risk assessment methodologies. The document is divided into three main subject areas: assessment of toxicity to female reproduction, assessment of toxicity to male reproduction, and assessment of toxicity to the conceptus. There are three supplemental parts: pharmacokinetics and epidemiologic considerations, which are common to all toxicological assessments, and a special section on the behavioral aspects of sexual development. The specific areas addressed are the potential adverse effects on the female and male reproductive systems as well as adverse effects on the developing conceptus. A broad range of problems and effects are discussed, including infertility, early resorption of the conceptus, and possible behavioral disorders producted by subtle changes in the biochemical environment of the fetus. Suggestions are given for improvement in standard toxicological protocols for evaluation of reproductive risks, identifies new concepts and procedures that can be immediately applicable, and designates those that need further expansion and development through research. Included is a discussion on the predictive ability of the tests in estimating risk.

• Research Organization: Oak Ridge National Lab., TN (USA); Environmental Protection Agency, Washington, DC (USA). Office of Research and Development
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5171784
• Report Number(s): ORNL/EIS-197; EPA/600/9-82-001; CONF-8010259-Summ.; CONF-801286-Summ.; ON: DE82007897
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
EPIDEMIOLOGY
FEMALES
FETUSES
MALES
MAMMALS
MAN
MATERIALS
ONTOGENESIS
PHARMACOLOGY
PRIMATES
REPRODUCTION
REPRODUCTIVE DISORDERS
RISK ASSESSMENT
TERATOGENS
TOXIC MATERIALS
TOXICITY
VERTEBRATES