Dissection of the mechanisms of immune injury in rheumatoid arthritis, using total lymphoid irradiation

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780310104· OSTI ID:5170111

Gaston, J S; Strober, S; Solovera, J J; Gandour, D; Lane, N; Schurman, D; Hoppe, R T; Chin, R C; Eugui, E M; Vaughan, J H

Eleven patients with intractable rheumatoid arthritis were treated with total lymphoid irradiation. After radiotherapy, there was a marked decrease in the number and function of peripheral blood helper/inducer (Leu-3+) T lymphocytes, in the spontaneous secretion of interleukin-1 by synovial biopsy specimens, and in the activity of the joint disease. In contrast, levels of IgM, IgA, and IgG rheumatoid factors and C3 concentrations in blood and synovial fluid samples did not change significantly after therapy with total lymphoid irradiation.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 5170111
• Journal Information: Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 31:1; ISSN ARHEA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOPSY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIAGNOSTIC TECHNIQUES
DISEASES
GROWTH FACTORS
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOKINES
MATERIALS
MEDICINE
MITOGENS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PATIENTS
PROTEINS
RADIOLOGY
RADIOTHERAPY
RHEUMATIC DISEASES
SECRETION
SKELETAL DISEASES
SOMATIC CELLS
THERAPY