Resting and hypercapnic rCBF in patients with unilateral occlusive disease of the internal carotid artery

Journal Article · Tue Mar 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:5169438

Keyeux, A; Laterre, C; Beckers, C

Regional cerebral blood flow was measured by the /sup 133/Xe inhalation technique in 15 patients with severe unilateral internal carotid artery stenosis (75%) or occlusion, and in the absence of evidence of any sign of occlusive disease in other main afferent cerebral arteries. A comparison with normal subjects showed that lowered resting flow in both hemispheres was a common finding in all patients. Interhemispheric asymmetry was present only in patients with occlusion and the precentral, posterior temporal, and occipital regions were the most seriously affected. The CO/sub 2/ reactivity was substantially reduced in both hemispheres of all stenotic and occluded patients, but occluded patients showed an increased reduction of CO/sub 2/ reactivity only in the ipsilateral hemisphere. In addition to an hypothetical age effect, the atherosclerotic involvement of the cerebral vascular system leads to a reduction of flow and loss of CO/sub 2/ reactivity in both hemispheres. In this context, the collateral supply capacity is not overloaded in case of a unilateral severe stenosis but fails in case of a unilateral occlusion of the internal carotid artery. A suitable estimate of the blood flow reduction as a result of occlusion is made by the hemispheric and regional laterality indices applied in resting and hypercapnia conditions. These indices could be used as indicators for endarterectomy or bypass surgery as well as a sensitive means for appreciating cerebral blood flow response to treatment.

• Research Organization: Univ. of Louvain Medical School, Brussels (Belgium)
• OSTI ID: 5169438
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTIAL PRESSURE
PATHOGENESIS
PATIENTS
RADIOISOTOPES
TRACER TECHNIQUES
VASCULAR DISEASES
XENON 133
XENON ISOTOPES