Influence of thyroid states on stress gastric ulcer formation
This study was designed to test the hypothesis that thyroid states may affect the acute development of gastric lesions induced by cold-resistant stress. Normal (euthyroid), hyperthyroid and hypothyroid rats were used. Gastric lesion incidence and severity was significantly increased in hypothyroid rats, whereas in contrast hyperthyroid rats developed significantly less gastric lesions. As anticipated, plasma levels of thyroxin (T/sub 4/) were significantly elevated in hyperthyroid rats, and undetectable in hypothyroid rats. Acute pretreatment with i.p. cimetidine, but not T/sub 4/ 1 h prior to stress completely prevented gastric lesions formation in hypothyroid rats. Finally, binding of /sup 3/H-dihydroalprenolol to ..beta..-adrenergic receptors on brain membranes prepared from frontal cortex was reduced by 20% in hypothyroid rats after 3 h of stress. These and other data contained herein suggest that thyroid hormones contribute to modulate the responsiveness of the gastric mucosa to stress. The increase rate of ulcerogenesis observed in hypothyroid rats appears to be mediated by gastric acid secretion. The central mechanism for this response may involve decreased brain nonadrenergic receptor function.
- Research Organization:
- Univ. of Southern California, Los Angeles (USA)
- OSTI ID:
- 5169372
- Journal Information:
- Life Sci.; (United States), Vol. 42:18
- Country of Publication:
- United States
- Language:
- English
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GASTROINTESTINAL TRACT
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BRAIN
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HYPERTHYROIDISM
HYPOTHYROIDISM
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINO ACIDS
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CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
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ENDOCRINE GLANDS
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HORMONES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
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ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
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550901* - Pathology- Tracer Techniques