Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children
- Harvard School of Public Health, Boston, MA (USA)
The effect of indoor nitrogen dioxide on the cumulative incidence of respiratory symptoms and pulmonary function level was studied in a cohort of 1,567 white children aged 7-11 years examined in six US cities from 1983 through 1988. Week-long measurements of nitrogen dioxide were obtained at three indoor locations over 2 consecutive weeks in both the winter and the summer months. The household annual average nitrogen dioxide concentration was modeled as a continuous variable and as four ordered categories. Multiple logistic regression analysis of symptom reports from a questionnaire administered after indoor monitoring showed that a 15-ppb increase in the household annual nitrogen dioxide mean was associated with an increased cumulative incidence of lower respiratory symptoms (odds ratio (OR) = 1.4, 95% confidence interval (95% Cl) 1.1-1.7). The response variable indicated the report of one or more of the following symptoms: attacks of shortness of breath with wheeze, chronic wheeze, chronic cough, chronic phlegm, or bronchitis. Girls showed a stronger association (OR = 1.7, 95% Cl 1.3-2.2) than did boys (OR = 1.2, 95% Cl 0.9-1.5). An analysis of pulmonary function measurements showed no consistent effect of nitrogen dioxide. These results are consistent with earlier reports based on categorical indicators of household nitrogen dioxide sources and provide a more specific association with nitrogen dioxide as measured in children's homes.
- OSTI ID:
- 5164928
- Journal Information:
- American Journal of Epidemiology; (United States), Vol. 134:2; ISSN 0002-9262
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHILDREN
RESPIRATORY SYSTEM DISEASES
LUNGS
DYNAMIC FUNCTION STUDIES
NITROGEN DIOXIDE
TOXICITY
AIR POLLUTION MONITORING
DISEASE INCIDENCE
ECOLOGICAL CONCENTRATION
INDOOR AIR POLLUTION
REGRESSION ANALYSIS
SEASONAL VARIATIONS
SEX DEPENDENCE
SYMPTOMS
AGE GROUPS
AIR POLLUTION
BODY
CHALCOGENIDES
DISEASES
MATHEMATICS
MONITORING
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
STATISTICS
VARIATIONS
540120* - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology