Measurement of regional myocardial blood flow in hypertrophic cardiomyopathy: Application of the first-pass flow model using ( sup 13 N)ammonia and PET

Journal Article · Sun Jan 01 04:00:00 EST 1989 · American Journal of Physiologic Imaging; (USA)

OSTI ID:5159012

Yoshida, K; Endo, M; Himi, T; Kagaya, A; Masuda, Y; Inagaki, Y; Fukuda, H; Iinuma, T; Yamasaki, T; Fukuda, N ^[1]

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1. Chiba Univ. School of Medicine (Japan)

Positron emission tomography (PET) has become an important tool in the study of regional myocardial blood flow. The purpose of the present study was to measure regional myocardial blood flow using dynamic ({sup 13}N)ammonia PET and the first-pass flow model. Thirteen patients with hypertrophic cardiomyopathy, and with a considerably thickened ventricular wall (25 mm or greater), were selected for the study in order to minimize errors due to spillover of radioactivity from blood to the myocardium and to the underestimation of myocardial activity caused by the partial volume effect. Arterial input function was determined by assigning a region of interest to the left atrial cavity on the PET images. Using left atrial and myocardial time-activity curves, regional myocardial blood flow was calculated using the first-pass flow model. Mean myocardial blood flow ranged from 47.8 to 76.5 ml/min per 100 g (63.0 +/- 9.4). Regional myocardial blood flow in the septum was significantly lower than in the anterior and lateral walls of the left ventricle (P less than .01). These results indicate the potential usefulness of dynamic PET in the measurement of regional myocardial blood flow in man.

• OSTI ID: 5159012
• Journal Information: American Journal of Physiologic Imaging; (USA), Journal Name: American Journal of Physiologic Imaging; (USA) Vol. 4:3; ISSN 0885-8276; ISSN AJPIE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMMONIA
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HYDRIDES
HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NITROGEN 13
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
TOMOGRAPHY