Pharmacokinetics and metabolism of benzene in Zymbal gland and other key target tissues after oral administration in rats

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.8982215· OSTI ID:5154466

Low, L K; Meeks, J R; Norris, K J; Mehlman, M A; Mackerer, C R ^[1]

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1. Mobil Oil Corporation, Princeton, NJ (USA)

Solid tumors have been reported in the Zymbal gland, oral and nasal cavities, and mammary gland of Sprague-Dawley rats following chronic oral administration of benzene. The cause for the specificity of such lesions remains unclear, but it is possible that tissue-specific metabolism or pharmacokinetics of benzene is responsible. Metabolism and pharmacokinetic studies were carried out in our laboratory with 14C-benzene at oral doses of 0.15 to 500 mg/kg to ascertain tissue retention, metabolite profile, and elimination kinetics in target and nontarget organs and in blood. Findings from those studies indicate the following: (a) the Zymbal gland is not a sink or a site of accumulation for benzene or its metabolites even after a single high dose (500 mg/kg) or after repeated oral administration; (b) the metabolite profile is quantitatively different in target tissues (e.g., Zymbal gland, nasal cavity), nontarget tissues and blood; and (c) pharmacokinetic studies show that the elimination of radioactivity from the Zymbal gland is biphasic.

• OSTI ID: 5154466
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 82; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL HALF-LIFE
BODY
BODY AREAS
CARBON 14 COMPOUNDS
CARCINOGENESIS
CHRONIC EXPOSURE
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
FACE
HEAD
HYDROCARBONS
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
METABOLITES
NEOPLASMS
NOSE
ORAL ADMINISTRATION
ORAL CAVITY
ORGANIC COMPOUNDS
PATHOGENESIS
RATS
RESPIRATORY SYSTEM
RODENTS
SPECIFICITY
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES