Intracranial metastases from melanoma. Clinical features and treatment by accelerated fractionation

Journal Article · Mon Jul 01 04:00:00 EDT 1985 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19850701)56:1<1::AID-CNCR2820560102>3.0.CO;2-X· OSTI ID:5149760

Choi, K N; Withers, H R; Rotman, M

One hundred ninety-four patients with intracranial metastatic melanoma were treated at the M. D. Anderson Hospital between January 1972 and September 1977, using seven different accelerated irradiation regimens. The total tumor dose varied from 3000 to 4800 rad, and the overall treatment time from 1 to 2 weeks. In these patients, whose disease had progressed to brain metastases, freedom from such metastases had decreased logarithmically with time from initial presentation. This suggests a random distribution of progression rates with a mean time of 2.5 years between diagnosis and development of intracranial metastases. Overall, there was no significant improvement in the results from accelerated fractionation in the treatment of intracranial metastases. The result of treatment did not depend on the site of the primary, the number of intracranial metastases, the total dose, or the dose per fraction. There were, however, two subgroups not mutually exclusive, that benefited significantly from the accelerated fractionation: patients having had a complete resection of brain metastases, and those having no detectable extracranial metastases at the time of their treatment for intracranial metastases.

• Research Organization: Univ. of Texas System Cancer Center, Houston
• OSTI ID: 5149760
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 1; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ATROPHY
AUTOPSY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
FRACTIONATED IRRADIATION
IRRADIATION
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
THERAPY