Interaction of Xylamine with peripheral sympathetic neurons

Journal Article · Mon Sep 30 00:00:00 EDT 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90128-6· OSTI ID:5147879

Ransom, R W; Waggaman, L A; Cho, A K

Xylamine (XYL) administered to intact rats caused a 70-80% reduction in norepinephrine (NE) uptake by the vas deferens but had little or no effect on NE content in that tissue. The vas deferens accumulates /sup 3/H-XYL in vitro by a desmethylimipramine (DMI)-sensitive mechanism. Vasa deferentia from 6-hydroxydopamine (60HDA) pretreated animals exhibited a 80% reduction in both NE content and XYL uptake activity. These results indicate that XYL is taken up by sympathetic nerve terminals and can reduce NE uptake activity without depleting terminals of neurotransmitter. 9 references, 4 tables.

• Research Organization: University of California, Los Angeles
• OSTI ID: 5147879
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 37:13; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
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DOPAMINE
DRUGS
GONADS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MALE GENITALS
MAMMALS
NERVES
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
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RATS
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STEROID HORMONES
SYMPATHOMIMETICS
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UPTAKE
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