Uptake, distribution and behavioral effects of inhalation exposure to manganese (MnO2) in the adult mouse
Adult male mice were exposed either to sublethal levels of MnO2 dust or filtered air (control group) 7 hours/day, 5 days/week for 16 to 32 weeks. Following a 16 week initial exposure period, randomly selected samples (8 animals) from both the control and Mn-exposed groups were observed for behavioral performance (ambulations and rearings in the open-field, ''hole-in-board'' explorations, rotarod) and learning (passive avoidance) and tissue Mn levels were determined via atomic absorption spectrometry. Exposure continued for the remaining animals and the sampling procedure was repeated biweekly for an additional 8 time points. At week 32, Mn exposure was terminated. However, biweekly testing of the remaining animals continued for an additional 3 time points. Mn-exposed animals had significantly higher blood, liver, kidney, lung, cerebrum, cerebellum plus brainstem, and testis Mn levels than control animals. With the exception of the liver, these levels declined with increasing exposure time. No histopathologic effects attributable to Mn-exposure were observed. However, significant overall effects on growth and behavior were obtained. When the post-exposure data were analyzed separately, no significant effects were obtained. While no general relationship was obtained between tissue Mn levels and behavior, selected behavioral measures did correlate with tissue Mn levels.
- Research Organization:
- SUNY-College, Buffalo
- OSTI ID:
- 5147701
- Journal Information:
- Neurotoxicology (Park Forest South, Ill.); (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MANGANESE OXIDES
BIOLOGICAL EFFECTS
TISSUE DISTRIBUTION
UPTAKE
MICE
BEHAVIOR
ABSORPTION SPECTROSCOPY
BLOOD
BRAIN
DUSTS
INHALATION
KIDNEYS
LIVER
LUNGS
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
INTAKE
MAMMALS
MANGANESE COMPOUNDS
MATERIALS
NERVOUS SYSTEM
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
SPECTROSCOPY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)