Bismuth induction of metallothionein in zinc marginal rats

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5145346

Foltz, T; Joseph, E; Yang, F L; DiSilvestro, R ^[1]

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1. Ohio State Univ., Columbus (United States)

Bismuth induced elevation of kidney metallothionein (MT) in mice correlates with protection against nephrotoxicity from the chemotherapy drug cisplatin. However, the effectiveness of such protection in humans undergoing chemotherapy could depend on the zinc status of the patients. Bismuth induced elevations in kidney MT were lower in growing rats fed a marginal zinc diet for 25 days as compared to those fed adequate zinc. Bismuth nitrate was given in two injections, 14 mg/kg each, 18 h apart. Rats were killed 24 h after the initial injection. Noninduced Mt concentrations were also lower in the marginal rats than in rats fed adequate zinc. The marginal rats consumed a little less food than the adequate rats, but weighed considerably less. Studies are presently underway to determine the role of MT mRNA accumulation, and MT protein degradation, in control of MT levels by bismuth in rats with varying zinc status.

• OSTI ID: 5145346
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BISMUTH
ELEMENTS
KINETICS
MAMMALS
MESSENGER-RNA
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RATS
REACTION KINETICS
RNA
RODENTS
SYNTHESIS
VERTEBRATES
ZINC