Overexpression of transforming growth factor-. beta. in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene

Journal Article · Tue Oct 01 00:00:00 EDT 1991 · Molecular and Cellular Biology; (United States)

DOI:https://doi.org/10.1128/MCB.11.10.5222· OSTI ID:5144773

Kim, Seongjin; Winokur, T S; Lee, Hyde; Danielpour, D; Kim, Kyung Young; Geiser, A G; Sporn, M B; Roberts, A B ^[1]; Chen, Liansheng; Jay, G ^[2]

---

1. National Cancer Inst., Bethesda, MD (United States)
2. Jerome H. Holland Lab., Rockville, MD (United States)

Human T-cell lymphotropic virus type I (HTLV-I) has been associated with an adult form of T-cell leukemia as well as tropical spastic paraparesis, a neurodegenerative disease. Adult T-cell leukemia patients express high levels of the type 1 isoform of transforming growth factor-{beta} (TGF-{beta}1), which is mediated by the effects of the HTLV-I Tax transactivator protein on the TGF-{beta}1 promoter. To understand further the regulation of TGF-{beta}1 expression by Tax, the authors examined its expression in transgenic mice carrying the HTLV-I tax gene. They show that tumors from these mice and other tissues, such as submaxillary glands and skeletal muscle, which express high levels of tax mRNA selectively express high levels of TGF-{beta}1 mRNA and protein. Moreover, TGF-{beta}1 significantly stimulated the incorporation of tritiated thymidine into one of three cells lines derived from neurofibromas of tax-transgenic mice, which suggest that the excessive production of TGF-{beta}1 may play a role in tumorigenesis and that these mice may serve as a useful model for studying the biological effects of TGF-{beta} in vivo.

• OSTI ID: 5144773
• Journal Information: Molecular and Cellular Biology; (United States), Vol. 11:10; ISSN 0270-7306
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CARCINOGENESIS
MOLECULAR BIOLOGY
GROWTH FACTORS
BIOLOGICAL EFFECTS
TRITIUM COMPOUNDS
UPTAKE
GENES
LEUKEMIA
LEUKEMIA VIRUSES
MAN
MESSENGER-RNA
MICE
PATIENTS
TUMOR CELLS
ANIMAL CELLS
ANIMALS
DISEASES
HYDROGEN COMPOUNDS
IMMUNE SYSTEM DISEASES
MAMMALS
MICROORGANISMS
MITOGENS
NEOPLASMS
NUCLEIC ACIDS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
PRIMATES
PROTEINS
RNA
RODENTS
VERTEBRATES
VIRUSES
550200* - Biochemistry