Effect of dietary manganese on tissue antioxidants in STZ diabetic rats
Conference
·
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:5144622
- Univ., of British Columbia, Vancouver (Canada)
The objective of this experiment was to investigate the effect of Mn deficiency on tissue antioxidant levels under conditions of STZ (streptozotocin)-induced diabetes. Weanling, male Sprague-Dawley rats were assigned randomly to 1 of 6 groups: (1) Mn+ (manganese-sufficient), nondiabetic; (2) Mn{minus} (manganese-deficient), nondiabetic; (3) Mn+, diabetic for 4 weeks; (4) Mn{minus}, diabetic for 4 weeks; (5) Mn+, diabetic for 8 weeks; and (6) Mn{minus}, diabetic for 8 weeks. Decreased Mn levels in all tissues of Mn{minus} rats were accompanied by decreased MnSOD activity in kidney and heart, but not in liver or pancreas. Hepatic vitamin E was progressively increased in 4 and 8-week diabetic rats. Overall, diabetogenic effects of STZ were not amplified by manganese deficiency.
- OSTI ID:
- 5144622
- Report Number(s):
- CONF-9104107--
- Conference Information:
- Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIOXIDANTS
BIOLOGICAL EFFECTS
DIABETES MELLITUS
DIET
DISEASES
DISTRIBUTION
ELEMENTS
ENDOCRINE DISEASES
ENZYME ACTIVITY
ENZYMES
MANGANESE
METABOLIC DISEASES
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PATHOGENESIS
PROTEINS
SUPEROXIDE DISMUTASE
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIOXIDANTS
BIOLOGICAL EFFECTS
DIABETES MELLITUS
DIET
DISEASES
DISTRIBUTION
ELEMENTS
ENDOCRINE DISEASES
ENZYME ACTIVITY
ENZYMES
MANGANESE
METABOLIC DISEASES
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PATHOGENESIS
PROTEINS
SUPEROXIDE DISMUTASE
TISSUE DISTRIBUTION
TRANSITION ELEMENTS