Effects of aluminum and nicotinic acid on bone minerals and growth in chicks
- Univ. of Hawaii, Honolulu (United States)
One-day old Brown Leghorn-Cross male chicks were divided into three groups of ten chicks for each of the following experimental treatments: control; .05% Al and AlCl{sub 3}; 1.5% nicotinic acid (nic); .05% Al + 1.5% nic (Alnic). A standard corn-soybean meal chick starter diet served as the basal diet. Feed consumption and growth rates were recorded during the 14-day study. Chicks were sacrificed at the end of the study. Tibias were taken, weighed, ashed and dissolved in dilute acid. The acid digests were analyzed for mineral content (P, Ca, Mg, Fe, Zn) using induction-coupled-plasma emission spectroscopy. There were no significant differences between treatments based on mineral content per gram of bone. Bone weights of the Alnic group were decreased by 33% as compared to the control and all other groups; control being 6.49 {plus minus} 1.28g and Alnic being 4.37 {plus minus} 1.32. Body weight was decreased by 21% in the Alnic group. Although Al or nic had no effect on mineral content of bone, the combination of Al and nic caused a decrease in bone weight of the chicks. The combination was more toxic than administrative of either Al or nic alone. This finding may be relevant to the use of nicotinic acid as a supplement when Al containing substances are ingested at the same time.
- OSTI ID:
- 5144493
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ALUMINIUM
BIOLOGICAL EFFECTS
CALCIUM
METABOLISM
IRON
MAGNESIUM
NICOTINIC ACID
PHOSPHORUS
ZINC
ANIMAL GROWTH
CHICKENS
EMISSION SPECTROSCOPY
SKELETON
ALKALINE EARTH METALS
ANIMALS
AZINES
BIRDS
BODY
CARBOXYLIC ACIDS
ELEMENTS
FOWL
GROWTH
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
METALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
SPECTROSCOPY
TRANSITION ELEMENTS
VERTEBRATES
VITAMIN B GROUP
VITAMINS
560300* - Chemicals Metabolism & Toxicology