Reversibility of the inhibitory effect of atrazine and lindane on cytosol 5. alpha. -dihydrotestosterone receptor complex formation in rat prostate

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01688260· OSTI ID:5138487

Simic, B; Kniewald, Z; Kniewald, J ^[1]; Davies, J E ^[2]

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1. Univ. of Zagreb, (Yugoslavia)
2. Univ. of Miami, FL (United States)

Once entering the bloodstream, most toxic substances, including pesticides, can reach organs involved in the reproductive system. They can cross the placenta, as well as the brain barrier, posing various risks to the reproductive processes. The organochlorine insecticide lindane and the s-triazine herbicide atrazine produce changes in hormone-dependent reactions in the rat hypothalamus, anterior pituitary, and prostate. Lindane also causes histological and biochemical alterations in the rat testis. In vivo treatment with atrazine produces a markedly inhibitory influence of 5{alpha}-dihydrotestosterone - receptor complex formation in rat prostate cytosol. Therefore, the aim of this study was to investigate whether such changes in the crucial step in the reproductive process are reversible. A parallel investigation using lindane was also undertaken.

• OSTI ID: 5138487
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 46:1; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHLORINATED ALICYCLIC HYDROCARBONS
ENDOCRINE GLANDS
FETAL MEMBRANES
GLANDS
HALOGENATED ALICYCLIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
HYPOTHALAMUS
INSECTICIDES
KETONES
LINDANE
MALE GENITALS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NERVOUS SYSTEM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
PITUITARY GLAND
PLACENTA
PROSTATE
PROTEINS
RATS
RECEPTORS
REPRODUCTION
RODENTS
STEROID HORMONES
STEROIDS
TESTOSTERONE
VERTEBRATES