Methionine adenosyltransferase activity of the rat liver under the influence of x-rays and the thioposphamide

Journal Article · Sat Jan 01 00:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5134202

Zelinskii, V G; Savitskii, I V

One group of rats was exposed to a total-body dose of 600R of x radiation and the animals were killed at intervals up to 30 days. A second group of rats was given intravenous injections of thiophosphamide and killed at intervals up to 10 days. Activity of methionine adenosyltransferase (MAT) in the liver was then assayed. There was a significant decrease in MAT activity 3 days following irradiation; in surviving animals the activity was normal after 30 days. Three days following administration of thiophosphamide there was an increase of enzyme activity; this was followed by a significant drop after 7 days. (HLW)

• Research Organization: Odessa Medical Inst.
• OSTI ID: 5134202
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Vol. 17:5; Other Information: Translated from Radiobiologiya; 17: No. 5, 776-779(1977)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOMIMETIC DRUGS
BIOLOGICAL EFFECTS
TRANSFERASES
BIOLOGICAL RADIATION EFFECTS
METABOLISM
LIVER
RATS
X RADIATION
ANIMALS
BODY
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
GLANDS
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals