Pulmonary responses of well-characterized asthmatic, atopic, and normal volunteers to sulfur dioxide; Implications for air quality risk assessment
- Rancho Los Amigos Hospital, Inc., Downey, CA (USA). Professional Staff Association
Numerous laboratory investigations have shown that sulfur dioxide (SO/sub 2/) induces bronchoconstriction and respiratory symptoms in exercising asthmatics. These effects appear to depend on dose rate (the product of exposure concentration and ventilation rate), and may occur at dose rates attainable during outdoor exercise in SO/sub 2/-polluted communities. Effects are rapid in onset, requiring no more than 5 min of exercise during exposure. Thus they may be induced by transient elevations of SO/sub 2/ levels, which may occur near large pollution sources even when longer-term average concentrations meet existing air quality standards. Even very mild asthmatics typically are far more sensitive to SO/sub 2/ than healthy volunteers. The authors discuss an investigation designed to expand and improve the dose-response information on SO/sub 2/. In comparison to earlier work it employed a larger, clinically more diverse population of volunteer subjects. Comparatively severe, medication-dependent asthmatics were included, whereas most prior studies have been limited to mild asthmatics. All subjects' clinical status was documented in detail, in a manner allowing comparison with the National Health survey of community populations. Each exposure condition was replicated to test consistency of response. Short-term lung function changes and respiratory systems were documented.
- OSTI ID:
- 5134140
- Report Number(s):
- CONF-870695-; CODEN: PRAPA
- Journal Information:
- Proceedings, Annual Meeting, Air Pollution Control Association; (USA), Vol. 1; Conference: 80. annual meeting of the Air Pollution Control Association, New York, NY (USA), 21-26 Jun 1987; Other Information: Technical Paper 87-32.8; ISSN 0193-9688
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
29 ENERGY PLANNING
POLICY AND ECONOMY
AIR POLLUTION
RISK ASSESSMENT
ENVIRONMENT
SAFETY
LUNGS
BIOLOGICAL EFFECTS
SULFUR DIOXIDE
AIR POLLUTION CONTROL
AIR QUALITY
ASTHMA
ENVIRONMENTAL EXPOSURE PATHWAY
ENVIRONMENTAL POLICY
HEALTH HAZARDS
HUMAN POPULATIONS
REGULATIONS
BODY
CHALCOGENIDES
CONTROL
DISEASES
ENVIRONMENTAL QUALITY
GOVERNMENT POLICIES
HAZARDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
POLLUTION CONTROL
POPULATIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SULFUR COMPOUNDS
SULFUR OXIDES
540120* - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology
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293000 - Energy Planning & Policy- Policy
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