Consideration of a tumor probability function and micro-dosimetry for the lower pulmonary compartment

Technical Report · Wed Dec 31 00:00:00 EST 1969

OSTI ID:5134074

Coleman, J R; Perez, Jr, L J ^[1]

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1. eds.

A new approach to evaluating the hazard from radioactive particulate inhalation is proposed. The approach is to assess the hazard by calculating the tumorigenicity of small particles based on a relationship for tumor probability per cell as a function of radiation dose. The method described uses data from experiments on rats to develop the needed tumor probability function for single cells. This probability function is then used to calculate the tumor probability for individual exposed cells (either skin or lung) and the summation for all exposed cells yields a total tumor probability for the exposure. Results are reported from studies using cultured HeLa cells, human conjunctiva and liver cells, rat lung and skin cells, and mouse skin cells exposed to a 1.0 micron particle of /sup 238/PuO/sub 2/ and an anatomical model of a human lung.

• Research Organization: NUS Corp., Washington, D.C. (USA)
• OSTI ID: 5134074
• Report Number(s): NUS-654
• Resource Relation: Other Information: Portion of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
CARCINOGENESIS
MAN
HEALTH HAZARDS
PLUTONIUM 238
BIOLOGICAL RADIATION EFFECTS
INTERNAL IRRADIATION
RADIOACTIVE AEROSOLS
INHALATION
BIOLOGICAL MODELS
CELL CULTURES
DOSE-RESPONSE RELATIONSHIPS
PATHOLOGICAL CHANGES
PLUTONIUM OXIDES
TESTING
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COLLOIDS
DISEASES
DISPERSIONS
EVEN-EVEN NUCLEI
HAZARDS
HEAVY NUCLEI
INTAKE
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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560201 - Thermal Effects- Cells- (-1987)