Utilization of 3-D elastic transformation in the registration of chest x-ray CT and whole body PET
- UCLA School of Medicine, Los Angeles, CA (United States); and others
X-ray CT is widely used for detection and localization of lesions in the thorax. Whole Body PET with 18-FDG is becoming accepted for staging of cancer because of its ability to detect malignancy. Combining information from these two modalities has a significant value to improve lung cancer staging and treatment planning. Due to the non-rigid nature of the thorax and the differences in the acquisition conventions, the subject is stretched non-uniformly and the images of these two modalities requires non-rigid transformation for proper registration. Techniques to register chest x-ray CT and Whole Body PET images were developed and evaluated. Accuracy of 3-D elastic transformation was tested by phantom study. Studies on patients with lung carcinoma were used to validate the technique in localizing the 18-FDG uptake and in correlating PET to x-ray CT images. The fused images showed an accurate alignment and provided confident identification of the detailed anatomy of the CT with the functional information of the PET images.
- DOE Contract Number:
- FC03-87ER60615
- OSTI ID:
- 513318
- Report Number(s):
- CONF-961123--; CNN: Grant R01-CA56655
- Country of Publication:
- United States
- Language:
- English
Similar Records
Automatic anatomy recognition in whole-body PET/CT images
Impact of FDG-PET/CT on Radiotherapy Volume Delineation in Non-Small-Cell Lung Cancer and Correlation of Imaging Stage With Pathologic Findings