Influence of brachytherapy ( sup 192 Ir afterloading) on cell-mediated immune reactions in patients with stage I endometrial cancer

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(89)90036-X· OSTI ID:5130194

Gerstner, G J; Kucera, H; Kudlacek, S; Micksche, M ^[1]

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1. Vienna Univ. Medical School (Austria)

The influence of radiation therapy on cell-mediated immune reactions in cancer patients seems to depend on source, dose, and area of irradiation, as well as on the variables reflected by the patient population investigated. In the present study we demonstrated that brachytherapy ({sup 192}Ir afterloading), applied to patients with inoperable stage I endometrial cancer, has no immediate or sustained effect on lymphocyte function. Both lymphocyte mitogen response and natural killer cell (NK) activity are not significantly changed in terms of baseline values compared with test results during and after therapy. Brachytherapy, as used in this study, has no influence on cell-mediated immunity in patients with endometrial cancer stage I.

• OSTI ID: 5130194
• Journal Information: Gynecologic Oncology; (USA), Vol. 35:2; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LYMPHOCYTES
BIOLOGICAL FUNCTIONS
NEOPLASMS
RADIOTHERAPY
UTERUS
AFTERLOADING
IMMUNE REACTIONS
IMMUNITY
IRIDIUM 192
PATIENTS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
FUNCTIONS
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION
ISOTOPES
LEUKOCYTES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
SOMATIC CELLS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)