Repeated inhalation exposure of mice to /sup 144/CeO/sub 2/

Journal Article · Tue Apr 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575242· OSTI ID:5129051

Hahn, F F; Lundgren, D L; McClellan, R O

Groups of mice (C57B1/6J strain) were repeatedly exposed by inhalation to aerosols of /sup 144/CeO/sub 2/ at 60-day intervals for seven consecutive exposures to reestablish lung burdens of /sup 144/Ce of 0.2, 1.0 or 4.5 ..mu..Ci. Additional groups of mice were exposed only once when 70 days old to achieve desired initial lung burdens of 0.2, 1.0, or 4.5 ..mu..Ci. Control mice consisted of those exposed once or repeatedly to stable CeO/sub 2/, sham-exposed once or repeatedly, and unexposed mice. Protraction of the absorbed radiation dose by repeated inhalation exposures resulted in a sparing from the life-shortening effects of /sup 144/Ce pulmonary irradiation. The protraction of dose had no effect on the total number of lung tumors seen or their time of onset. The total incidence of lung tumors, benign and malignant, was correlated with cumulative dose, not dose rate.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: EY-76-C-04-1013
• OSTI ID: 5129051
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CERIUM 144
CERIUM COMPOUNDS
CERIUM ISOTOPES
CERIUM OXIDES
CHALCOGENIDES
CUMULATIVE RADIATION EFFECTS
DATA
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
INFORMATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RARE EARTH COMPOUNDS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES