Dual-trap design and its applications in electrospray ionization FTICR mass spectrometry

Journal Article · Tue Apr 01 04:00:00 EST 1997 · Analytical Chemistry (Washington)

DOI:https://doi.org/10.1021/ac960941n· OSTI ID:512889

Gorshkov, M V; Pasa-Tolic, L; Bruce, J E; Anderson, G A; Smith, R D ^[1]

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1. Pacific Northwest National Lab., Richland, WA (United States)

A new arrangement consisting of two separate Fourier transform ion cyclotron resonance (FTICR) ion traps was used to develop methods for the manipulation of the ions produced by an electrospray ionization source (ESI). A first, `accumulation` trap, is generally maintained at a higher pressure than the second, high-performance `analyzer` trap. The manipulations developed and demonstrated include the following: (1) mass-selective ion transfers between the traps; (2) mass-selective step-wise accumulation of low-abundance ions of different mass-to-charge ratios transferred from the first trap to the analyzer trap; (3) simultaneous detection of ions in the analyzer trap and ion accumulation in the source trap; (4) simultaneous ion detection in the accumulation trap and ion storage in the analyzer trap; (5) sequential multiple transfers of the ions into the analyzer trap from the same ion population stored in the accumulation trap; (6) collision-induced dissociation of ions stored in the accumulation trap followed by mass-selective transfer of the product ions into the analyzer trap; and (7) sequential transfer of the ions of different mass-to-charge ratios into the analyzer trap from the same ion population stored in the accumulation trap followed by the collision-induced dissociation of transferred ions in the analyzer trap. 22 refs., 9 figs.

• DOE Contract Number: AC06-76RL01830
• OSTI ID: 512889
• Journal Information: Analytical Chemistry (Washington), Journal Name: Analytical Chemistry (Washington) Journal Issue: 7 Vol. 69; ISSN ANCHAM; ISSN 0003-2700
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
55 BIOLOGY AND MEDICINE
BASIC STUDIES
ABUNDANCE
BIOCHEMISTRY
DESIGN
FOURIER TRANSFORM SPECTROMETERS
ION CYCLOTRON RESONANCE SPECTROSCOPY
IONIZATION
MASS SPECTROMETERS
MASS SPECTROSCOPY
POLYMERS
SPRAYS
TRAPS