Effects of acute ethanol administration of female rat liver as a function of aging

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(89)90024-6· OSTI ID:5128220

Rikans, L E; Snowden, C D ^[1]

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1. Univ. of Oklahoma College of Medicine, Oklahoma City (USA)

Female Fischer 344 rats, aged 4, 14, and 25 months, received 4.0 g/kg of ethanol by intraperitoneal (i.p.) injection. Blood alcohol concentrations 2.5, 6 and 16 hr after ethanol injection were similar in the three age groups. Hepatic glutathione (GSH) levels were diminished 6 hr after ethanol injection, and there were no age-dependent differences in the depleted levels (3.2 {plus minus} 0.1, 3.5 {plus minus} 0.2, and 3.0 {plus minus} 0.5 {mu}g GSH/g liver). However, GSH contents in livers of young-adult rats approached control levels after 16 hr, whereas they remained depressed in older rats. Serum levels of hepatic enzymes were significantly elevated 6 hr after ethanol administration. The increases were greater in middle-aged and old rats than in young-adult rats. The results suggest that middle-aged and old rats are more susceptible than young rats to the acute toxicity of ethanol.

• OSTI ID: 5128220
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 45:15; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AGE DEPENDENCE
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
DRUGS
ETHANOL
GLANDS
GLUTATHIONE
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LIVER
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SYNTHESIS
TOXICITY
VERTEBRATES