Sensitivity of Drosophila melanogaster to low concentrations of the gaseous 1,2-dibromoethane. I. Acute exposures

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860010107· OSTI ID:5125446

Kale, P; Baum, J W

Drosophila melanogaster males were exposed to gaseous 1,2-dibromoethane at concentrations lower than those used in aerosol treatments of suspected mutagens by other investigators. Premeiotic stages appear to be more sensitive than postmeiotic stages to gaseous mutagens. At an exposure of 125 ppM.h, significant number of mutations were induced in spermatids, spermatocytes, and spermatogonia. Since this exposure increased the mutation rate in spermatogonial stages by a factor of 20 to 40 over the spontaneous rate, it appears that the lowest detectable exposures may be much lower than 125 ppM.h for 1,2-dibromoethane.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 5125446
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 1; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKANES
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGY
BROMINE COMPOUNDS
CELL DIVISION
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DROSOPHILA
EXPOSURE CHAMBERS
FLIES
FRUIT FLIES
GAMETES
GENETIC EFFECTS
GENETICS
GERM CELLS
HALOGEN COMPOUNDS
HYDROCARBONS
INHALATION
INSECTS
INTAKE
INVERTEBRATES
MEIOSIS
METHANE
MUTAGENESIS
MUTANTS
MUTATIONS
ORGANIC COMPOUNDS
SENSITIVITY
SOLS
SPERMATOCYTES
SPERMATOGONIA
SPERMATOZOA