European survey on the usefulness of /sup 67/Ga lung scans in assessing sarcoidosis. Experience in 14 research centers in seven different countries
Journal Article
·
· Ann. N.Y. Acad. Sci.; (United States)
Fifty-eight contributors from 12 European and 2 American sarcoidosis centers have collaborated in a survey to define many questions concerning the use of /sup 67/Ga lung scan in sarcoidosis. The new quantitative scoring methods based on digital evaluation seem better in detecting lung activity. In 20.1% of untreated patients, the /sup 67/Ga lung scan appeared to be the only noninvasive method with which clinical activity could be detected. /sup 67/Ga scans may be useful in guiding lung biopsy and in choosing pulmonary segments for BAL. Of 382 patients studied during follow-up (154 patients with three to nine scans at intervals of 2 to 12 months), the /sup 67/Ga scan was far more sensitive than chest radiography, both in detecting improvement and in foreseeing relapses. Steroid therapy appears to suppress ACE levels more than /sup 67/Ga uptake, and /sup 67/Ga uptake more than the alveolitis detectable by BAL. Gallium-67 uptake rebounds to positivity occur in about 40% of patients after steroid discontinuation and in about 20% of patients after steroid reduction to daily doses of 10 mg or less of prednisone. The /sup 67/Ga dose of 1.5 mCi seems appropriate for clinical purposes and is recommended for the subjective scoring method in order to reduce the cost and the radiation burden.
- OSTI ID:
- 5123875
- Journal Information:
- Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States); ISSN ANYAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
BRONCHI
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EUROPE
EVALUATION
FEDERAL REGION II
FEDERAL REGION III
GALLIUM 67
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
NEW YORK
NEW YORK CITY
NORTH AMERICA
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PENNSYLVANIA
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
UPTAKE
USA
USES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
BRONCHI
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EUROPE
EVALUATION
FEDERAL REGION II
FEDERAL REGION III
GALLIUM 67
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
NEW YORK
NEW YORK CITY
NORTH AMERICA
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PENNSYLVANIA
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
UPTAKE
USA
USES