Alloantigen-specific suppressor T cells are not inhibited by cyclosporin A, but do require IL 2 for activation
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5120683
Alloantigen-specific suppressor T cells are activated from normal murine spleen cells in mixed lymphocyte reactions (MLR). These T cells are radioresistant and suppress the activation of cytotoxic T lymphocytes (CTL) in second primary MLR cultures. This report demonstrates that cyclosporin A (CsA) blocks the activation of these suppressor cells at a dose of 1 microgram/ml. However, reconstitution of CsA blocked cultures with IL 2 restores the activation of the suppressor T cells, but fails to significantly restore the activation of CTL in these same cultures. This differential activation requirement was used to establish T cell lines that demonstrate enriched suppressor cell activity but depletion of CTL activity. These findings are discussed in terms of the mechanism of action of CsA in these distinct T cell subsets and the relevance to models of allograft unresponsiveness.
- OSTI ID:
- 5120683
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 3; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nature of the suppressor cells mediating prolonged graft survival after administration of extracted histocompatibility antigen and cyclosporine
Functional clonal deletion versus suppressor cell-induced transplantation tolerance in chimeras prepared with a short course of total-lymphoid irradiation
Cyclosporine suppression of lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions
Journal Article
·
Thu Jan 31 23:00:00 EST 1985
· Transplantation; (United States)
·
OSTI ID:5726733
Functional clonal deletion versus suppressor cell-induced transplantation tolerance in chimeras prepared with a short course of total-lymphoid irradiation
Journal Article
·
Sun Jun 01 00:00:00 EDT 1986
· Transplantation; (United States)
·
OSTI ID:5230942
Cyclosporine suppression of lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions
Journal Article
·
Mon Aug 01 00:00:00 EDT 1983
· Surgery; (United States)
·
OSTI ID:5545838
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ACTIVATION
CONNECTIVE TISSUE CELLS
DRUGS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ACTIVATION
CONNECTIVE TISSUE CELLS
DRUGS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES