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Effect of cadmium and lead on copper and zinc metabolism

Journal Article · · Trace Element Metab Anim Proc Int Symp; (United States)
OSTI ID:5118043

Zinc and copper are biologically essential elements for man, animals, and plants, and are transported and utilized in living organisms as metalloproteins or metal complexes. Because of the vital nature of these elements and their presence in minute quantities as coordinate covalent complexes, their function is vulnerable to the action of many chemicals and competing transition metals to which an organism may be exposed. The inhibitory effects of these agents may simulate in many ways the deficiency state which can be nutritionally produced for zinc and copper, a situation which permits the quantitation of the inhibitory activity. On the other hand, cadmium and lead are toxic heavy metals which are widely distributed in the environment, the biological effects of which are considered to be among the most insidious of environmental hazards. It is to explore the extent to which lead and cadmium exhibit some of their toxic effects by virtue of their inhibition of the essential metabolic functions of zinc and copper that this report is made. 40 references.

Research Organization:
Univ. of Cincinnati, OH
OSTI ID:
5118043
Journal Information:
Trace Element Metab Anim Proc Int Symp; (United States), Journal Name: Trace Element Metab Anim Proc Int Symp; (United States) Vol. 2
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD SERUM
CADMIUM
CERULOPLASMIN
CHOLESTEROL
COMPLEXES
COPPER
COPPER COMPLEXES
DATA
ELEMENTS
EXPERIMENTAL DATA
GLOBULINS
GLOBULINS-ALPHA
GROWTH
HYDROXY COMPOUNDS
INFORMATION
IRON
LEAD
MAMMALS
METABOLISM
METALLOPROTEINS
METALS
NUMERICAL DATA
NUTRITION
ORGANIC COMPOUNDS
PROTEINS
RATS
RODENTS
STEROIDS
STEROLS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
ZINC