Possible effects of fluorides on the thyroid

McLaren, J R

Title: Possible effects of fluorides on the thyroid

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Abstract

A review of the literature on the relationship of fluorides and the thyroid gland reveals that the fluoride concentration within the thyroid gland on a wet basis is frequently at levels approximating, or above, those of blood and also, frequently, above those of other tissues including the kidneys. According to some investigators the fluoride concentration in the thyroid decreases at a slower rate than in other organs once animals are removed from fluoride intake. Fluoride appears to be actively concentrated by some of the thyroid cells and metabolized into such a form that it is not lost as readily as it is from other tissues when blood levels decrease. Fluorides at sufficient concentration produce profound morphological changes in the thyroid. The lower level of fluoride intake at which this may occur is open to discussion. Functional changes, however, may be seen frequently at daily intakes of 5 mg. Changes in activity of adenyl-cyclase concentrations are frequently encountered in thyroid glands at current levels of fluoride pollution. To date, analytical methods have not permitted these changes to be shown in vivo.

Authors:: McLaren, J R

Publication Date:: 1976-04-01

OSTI Identifier:: 5117956

Resource Type:: Journal Article

Journal Name:: Fluoride; (United States)

Additional Journal Information:: Journal Volume: 9:2

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYCLASES; ENZYME ACTIVITY; FLUORIDES; BIOLOGICAL EFFECTS; TISSUE DISTRIBUTION; THYROID; MORPHOLOGICAL CHANGES; BLOOD; METABOLISM; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; DISTRIBUTION; ENDOCRINE GLANDS; ENZYMES; FLUORINE COMPOUNDS; GLANDS; HALIDES; HALOGEN COMPOUNDS; LYASES; MATERIALS; ORGANS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

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                    McLaren, J R. Possible effects of fluorides on the thyroid.  United States: N. p., 1976. 
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                    McLaren, J R. Possible effects of fluorides on the thyroid.  United States.

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                    McLaren, J R. 1976.  
        "Possible effects of fluorides on the thyroid".  United States.

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@article{osti_5117956,

  title        = {Possible effects of fluorides on the thyroid},

  author       = {McLaren, J R},

  abstractNote = {A review of the literature on the relationship of fluorides and the thyroid gland reveals that the fluoride concentration within the thyroid gland on a wet basis is frequently at levels approximating, or above, those of blood and also, frequently, above those of other tissues including the kidneys. According to some investigators the fluoride concentration in the thyroid decreases at a slower rate than in other organs once animals are removed from fluoride intake. Fluoride appears to be actively concentrated by some of the thyroid cells and metabolized into such a form that it is not lost as readily as it is from other tissues when blood levels decrease. Fluorides at sufficient concentration produce profound morphological changes in the thyroid. The lower level of fluoride intake at which this may occur is open to discussion. Functional changes, however, may be seen frequently at daily intakes of 5 mg. Changes in activity of adenyl-cyclase concentrations are frequently encountered in thyroid glands at current levels of fluoride pollution. To date, analytical methods have not permitted these changes to be shown in vivo.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5117956},
  journal      = {Fluoride; (United States)},
number       = ,

  volume       = 9:2,

  place        = {United States},

  year         = {1976},

  month        = {4}

}

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