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Use of gamma-hexachlorocyclohexane (lindane) to determine the ontogeny of metabolism in the developing rat

Journal Article · · J. Toxicol. Environ. Health; (United States)
; ; ; ;
The compound lindane (gamma-hexachlorocyclohexane) has been used to study the ontogeny of metabolism in the developing Fischer 344 rat. The distribution and metabolic fate of lindane at 2, 9, 16, and 23 d of age was investigated following subcutaneous administration of lindane at 20 mg/kg containing 0.5 microCi (U-/sup 14/C)lindane in peanut oil. Groups of 10 pups (5 male and 5 female) were sacrificed at 4-h intervals during the 24-h period following dosing. Adrenals, blood, brain, heart, lung, liver, and kidneys were analyzed for radioactivity. Urine samples were analyzed for radioactivity and metabolites of lindane. There was a significant age-dependent increase in the metabolism of lindane in the rat. High levels of radioactivity in the lung and increased reductive dechlorination suggest that the lung may play a greater role in metabolism of lindane by young rats. Oxidative phase I reactions increased significantly, while anaerobic reductive dechlorination of lindane to 4-chlorophenylmercapturic acid decreased significantly with age. Phase II sulfate and glutathione conjugations decreased significantly and glucuronide conjugation increased significantly with age. Metabolism and excretion of lindane appear to parallel development of the hepatic enzymes involved in phase I and phase II reactions.
Research Organization:
Environmental Protection Agency, Research Triangle Park, NC
OSTI ID:
5116090
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CARBON 14 COMPOUNDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHLORINATED ALICYCLIC HYDROCARBONS
DIGESTIVE SYSTEM
DISTRIBUTION
ENDOCRINE GLANDS
GLANDS
HALOGENATED ALICYCLIC HYDROCARBONS
HEART
INSECTICIDES
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LINDANE
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
NERVOUS SYSTEM
ONTOGENESIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES