Gas chromatographic and mass spectrometric analysis of polychlorinated biphenyls in human placenta and cord blood

Journal Article · Wed Oct 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80163-3· OSTI ID:5115420

Ando, M; Saito, H; Wakisaka, I

Gas chromatographic and mass spectrometric analyses of polychlorinated biphenyls (PCBs) in placenta, maternal blood, cord blood, and milk were carried out. Trichlorobiphenyl, tetrachlorobiphenyl, pentachlorobiphenyls, and hexachlorobiphenyls were identified by the mass chromatogram and the mass spectra. Some minor peaks of PCBs were identified by gas chromatography. The relationship between the PCB concentration in placenta and that in milk is different in each PCB congener. The higher the chlorine content of the PCB congener, the more significant the correlation. No significant but a low negative correlation exists between the concentration of some PCB congeners in the placenta and that in cord blood. On the other hand, a significant linear correlation exists between the concentration of hexachlorobenzene in the placenta and that in cord blood. The transplacental transport of each PCB congener varied depending upon its chemical nature. Trichlorobiphenyl and tetrachlorobiphenyl were more transferable than hexachlorobiphenyls. The results show that the placenta and cord blood are useful human samples to analyze the body burden of environmental pollutants and to estimate their transfer from mother to fetus.

• Research Organization: National Institute for Environmental Studies, Ibaraki, Japan
• OSTI ID: 5115420
• Journal Information: Environ. Res.; (United States), Vol. 41:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD
GAS CHROMATOGRAPHY
MASS SPECTROSCOPY
CHLORINATED AROMATIC HYDROCARBONS
MEMBRANE TRANSPORT
FETAL MEMBRANES
MILK
BODY BURDEN
EXPERIMENTAL DATA
STRUCTURE-ACTIVITY RELATIONSHIPS
AROMATICS
BIOLOGICAL MATERIALS
BODY FLUIDS
CHROMATOGRAPHY
DATA
FOOD
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
MATERIALS
MEMBRANES
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SEPARATION PROCESSES
SPECTROSCOPY
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)