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Gas chromatographic and mass spectrometric analysis of polychlorinated biphenyls in human placenta and cord blood

Journal Article · · Environ. Res.; (United States)
; ;

Gas chromatographic and mass spectrometric analyses of polychlorinated biphenyls (PCBs) in placenta, maternal blood, cord blood, and milk were carried out. Trichlorobiphenyl, tetrachlorobiphenyl, pentachlorobiphenyls, and hexachlorobiphenyls were identified by the mass chromatogram and the mass spectra. Some minor peaks of PCBs were identified by gas chromatography. The relationship between the PCB concentration in placenta and that in milk is different in each PCB congener. The higher the chlorine content of the PCB congener, the more significant the correlation. No significant but a low negative correlation exists between the concentration of some PCB congeners in the placenta and that in cord blood. On the other hand, a significant linear correlation exists between the concentration of hexachlorobenzene in the placenta and that in cord blood. The transplacental transport of each PCB congener varied depending upon its chemical nature. Trichlorobiphenyl and tetrachlorobiphenyl were more transferable than hexachlorobiphenyls. The results show that the placenta and cord blood are useful human samples to analyze the body burden of environmental pollutants and to estimate their transfer from mother to fetus.

Research Organization:
National Institute for Environmental Studies, Ibaraki, Japan
OSTI ID:
5115420
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 41:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BODY BURDEN
BODY FLUIDS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
DATA
EXPERIMENTAL DATA
FETAL MEMBRANES
FOOD
GAS CHROMATOGRAPHY
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
MASS SPECTROSCOPY
MATERIALS
MEMBRANE TRANSPORT
MEMBRANES
MILK
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SEPARATION PROCESSES
SPECTROSCOPY
STRUCTURE-ACTIVITY RELATIONSHIPS