Lead exposure and the central auditory processing abilities and cognitive development of urban children: the Cincinnati Lead Study cohort at age 5 years

Journal Article · Wed Jan 01 04:00:00 EST 1992 · Neurotoxicology and Teratology; (United States)

DOI:https://doi.org/10.1016/0892-0362(92)90028-9· OSTI ID:5109756

Dietrich, K N; Succop, P A; Berger, O G; Keith, R W ^[1]

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1. University of Cincinnati College of Medicine, Department of Environmental Health, OH (United States)

This analysis examined the relationship between lead exposure as registered in whole blood (PbB) and the central auditory processing abilities and cognitive developmental status of the Cincinnati cohort (N = 259) at age 5 years. Although the effects were small, higher prenatal, neonatal, and postnatal PbB levels were associated with poorer central auditory processing abilities on the Filtered Word Subtest of the SCAN (a screening test for auditory processing disorders). Higher postnatal PbB levels were associated with poorer performance on all cognitive developmental subscales of the Kaufman Assessment Battery for Children (K-ABC). However, following adjustment for measures of the home environment and maternal intelligence, few statistically or near statistically significant associations remained. Our findings are discussed in the context of the related issues of confounding and the detection of weak associations in high risk populations.

• OSTI ID: 5109756
• Journal Information: Neurotoxicology and Teratology; (United States), Journal Name: Neurotoxicology and Teratology; (United States) Vol. 14:1; ISSN 0892-0362; ISSN NETEE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHILDREN
DEVELOPED COUNTRIES
ELEMENTS
ENVIRONMENTAL EXPOSURE
LEAD
MATERIALS
MATHEMATICS
METABOLISM
METALS
NERVOUS SYSTEM
NORTH AMERICA
OHIO
ORGANS
REGRESSION ANALYSIS
STATISTICS
TOXICITY
URBAN AREAS
USA