Glucan: mechanisms involved in its radioprotective effect
Technical Report
·
OSTI ID:5102934
It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability to resist life-threatening opportunistic infections. However, using glucan as a hemopoietic stimulant/radioprotectant, the authors demonstrated the host resistance to opportunistic infection is enhanced in mice even prior to the detection of significant hemopoietic regeneration. This early enhanced resistance microbial invasion in glucan-treated irradiated mice could be correlated with enhanced and/or prolonged macrophage (but not granulocyte) function. These results suggest that early after irradiation glucan may mediate its radioprotection by enhancing resistance to microbial invasion via mechanisms not necessarily predicated on hemopoietic recovery. In addition, preliminary evidence suggests that glucan can also function as an effective free-radical scavenger. Because macrophages have been shown to selectively phagocytize and sequester glucan, the possibility that these specific cells may be protected by virtue of glucan's scavenging ability is also suggested.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 5102934
- Report Number(s):
- AD-A-186541/9/XAB; AFRRI-SR-87-29
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DETECTION
DISEASES
DRUGS
DYNAMICS
ENDOTOXINS
HEMATOPOIETIC SYSTEM
IMMUNITY
INFECTIOUS DISEASES
MAMMALS
MATERIALS
MECHANICS
MICE
MICROORGANISMS
PHAGOCYTES
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
TOXIC MATERIALS
TOXINS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DETECTION
DISEASES
DRUGS
DYNAMICS
ENDOTOXINS
HEMATOPOIETIC SYSTEM
IMMUNITY
INFECTIOUS DISEASES
MAMMALS
MATERIALS
MECHANICS
MICE
MICROORGANISMS
PHAGOCYTES
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
TOXIC MATERIALS
TOXINS
VERTEBRATES