Validation of doubly labeled water for measuring energy expenditure during parenteral nutrition

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5095083

Schoeller, D A; Kushner, R F; Jones, P J

The doubly labeled water method was compared with intake-balance for measuring energy expenditure in five patients receiving total parenteral nutrition (TPN). Because parenteral solutions were isotopically different from local water, patients had to be placed on TPN at least 10 days before the metabolic period. Approximately 0.1 g 2H2O and 0.25 g H2(18)O per kg total body water were given orally. We collected saliva before, 3 h, and 4 h after the dose for measurement of total body water and urine before, 1 day, and 14 days after the dose for measurement of isotope eliminations. On day 14, total body weight was remeasured and change in body energy stores was calculated, assuming constant hydration. Intake was assessed from weights of TPN fluids plus dietary record for any oral intake. Energy expenditure from doubly labeled water (+/- SD) averaged 3 +/- 6% greater than intake-balance. Doubly labeled water method is a noninvasive, nonrestrictive method for measuring energy expenditure in patients receiving TPN.

• OSTI ID: 5095083
• Journal Information: Am. J. Clin. Nutr.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY COMPOSITION
MEASURING METHODS
WATER
DEUTERIUM COMPOUNDS
DOUBLE LABELLING
INTRAVENOUS INJECTION
NUTRIENTS
PATIENTS
TRACER TECHNIQUES
HYDROGEN COMPOUNDS
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLING
OXYGEN COMPOUNDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics