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Cadmium-induced hepatotoxicity

Thesis/Dissertation ·
OSTI ID:5090705
Time-course and dose-response studies in rats were conducted to evaluate Cd-induced hepatotoxicty. Morphological and biochemical evidence of liver injury occurred soon after a high dose of Cd and by ten hr severe hepatic necrosis was evident. Plasma enzyme activities of alanine (ALT) and aspartate (AST) aminotransferase paralleled morphological changes. Data indicate the liver is a major target organ of chronic Cd-poisoning and suggest that Cd-induced liver injury may play an important role in the nephrotoxicity observed after chronic exposure to Cd.
Research Organization:
Kansas Univ., Lawrence (USA)
OSTI ID:
5090705
Country of Publication:
United States
Language:
English