Dose-rate effects in synchronous mammalian cells in culture. II. A comparison of the life cycle of HeLa cells during continuous irradiation or multiple-dose fractionation. [Gamma radiation]

Journal Article · Thu Sep 01 00:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574623· OSTI ID:5090187

Mitchell, J B; Bedford, J S

The life cycle of synchronized S3 HeLa cells was examined during continuous irradiation at a dose rate of approximately 37 rad/hr and during multiple dose fractionation schedules of the same average dose rate (total dose / overall time = average dose rate). For all regimes given at this dose rate the effects on the life cyclee were similar. Cells progressed through G1 and S without appreciable delay and experienced a minimum G2 delay of about 10 hr. Cells eventually entered mitosis but virtually none were able to complete a successful division.

• Research Organization: Vanderbilt Univ. Hospital, Nashville
• OSTI ID: 5090187
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
COMPARATIVE EVALUATIONS
DOSE RATES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
GAMMA RADIATION
HELA CELLS
IONIZING RADIATIONS
IRRADIATION
LIFE CYCLE
RADIATION EFFECTS
RADIATIONS
SYNCHRONOUS CULTURES