Metabolism of nephrotoxic cis- and trans-decalin in Fischer-344 rats

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530868· OSTI ID:5088678

Olson, C T; Yu, K O; Serve, M P

The cis- and trans-decalin stereoisomers have found any uses as solvents and fuel components. The metabolism of the decalin isomers in male and female Fischer-344 rats and the effects of the decalins on renal damage were evaluated. Only male rats had kidney damage. Metabolism of cis-decalin yielded cis, trans-1-decalol and cis,cis-2-decalol in the urine of both sexes, with the male also producing cis,cis-1-decalol. The urinary metabolites of trans-decalin included trans,cis-2-decalol in both male and female rats and trans,trans-1-decalol in males. Extracts of kidney homogenates from male rats, but not from females, dosed with cis- and trans-decalin yielded cis-2-decalone and trans-2-decalone, respectively. A single male rat treated with trans-decalin produced no 2-decalone in the kidney extract and also showed no renal damage.

• Research Organization: Aerospace Medical Research Lab., Wright-Patterson AFB, OH
• OSTI ID: 5088678
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 18:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DECALIN
METABOLISM
TOXICITY
KIDNEYS
INJURIES
ENANTIOMORPHS
HOMOGENATES
METABOLITES
RATS
SEX DEPENDENCE
ALKANES
ANIMALS
BODY
CYCLOALKANES
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)