Effects of whole-body x irradiation on the biogenesis of creatine in the rat

Journal Article · Wed Jun 01 00:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574642· OSTI ID:5087501

Thyagarajan, P; Vakil, U K; Sreenivasan, A

Influences of whole-body x irradiation on various aspects of creatine metabolism have been studied. Exposures to sublethal or lethal doses of x radiation results in excessive urinary excretion as well as higher accumulation of creatine in the skeletal muscle of x-irradiated rats. A sudden fall in CPK activity in muscle with a concomitant rise in serum suggests that changes in serum and tissue CPK activity are of an adaptive nature in rats exposed to sublethal doses of x radiation. In vitro studies on creatine synthesis shows that transaminidase and methyl transferase activities in kidneys and liver, respectively, are decreased on the 5th day in the x-irradiated, are decreased on the 5th day in the x-irradiated rat. However, on the 8th day, the enzyme activities are restored to normal.

• Research Organization: Bhabha Atomic Research Center, Bombay
• OSTI ID: 5087501
• Journal Information: Radiat. Res.; (United States), Vol. 70:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CREATINE
BIOLOGICAL RADIATION EFFECTS
PHOSPHOTRANSFERASES
TRANSFERASES
BIOSYNTHESIS
METABOLISM
MUSCLES
RATS
WHOLE-BODY IRRADIATION
X RADIATION
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
ELECTROMAGNETIC RADIATION
ENZYMES
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNTHESIS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals