Gallium-67 complexes as radioactive markers to assess gastric and colonic transit

Journal Article · Wed Mar 01 00:00:00 EST 1995 · Journal of Nuclear Medicine

OSTI ID:508544

Bellen, J C; Chatterton, B E; Penglis, S; Tsopelas, C ^[1]

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1. Royal Adelaide Hospital (Australia)

Constipation and gastroparesis are gastrointestinal tract disorders that can be assessed by using radioactive markers in conjunction with scintigraphic techniques. Indium-111-DTPA is the radiopharmaceutical of choice for treating colonic transit in constipated patients, but it is an expensive product and its availability has been unreliable. Indium-113m-DTPA was the tracer used in our study to determine the liquid gastric emptying rate in dual-isotope solid-liquid emptying studies, however, cessation of the {sup 113}Sn/{sup 113m}In generator production makes it unavailable. Thus, development of alternative tracers to {sup 111}In-DTPA and {sup 113m}In-DTPA was essential. Gallium-67-citrate and {sup 67}Ga-EDTA were compared to {sup 111}In-DTPA to assess their efficacy for exclusive retention in the GI tract. These markers were orally administered into rats and their three-day cumulative fecal excretion, urine excretion and carcass retention were measured. An in vitro gastric emptying model was used to determine liquid phase partitioning of {sup 113m}In-DTPA, {sup 67}Ga-citrate and {sup 67}Ga-EDTA at 37{degrees}. Gallium-67-citrate was predominantly excreted in the feces (97.2% {+-} 0.2%) after three days, with negligible urine excretion (0.1% {+-} 0.0%) and carcass retention (0.6% {+-} 0.2%). These results are analogous to those obtained for {sup 111}In-DTPA for fecal excretion (96.7% {+-} 2.6%), urine excretion (0.6% {+-} 0.0%) and retention in the carcass (0.2% {+-} 0.0%). Gallium-67-EDTA showed similar partitioning in the liquid phase of the gastric emptying model compared with {sup 113m}In-DTPA. Gallium-67-citrate is an economical and readily available alternative to {sup 111}In-DTPA as a colonic transit radiopharmaceutical. Gallium-67-EDTA is also an alternative to {sup 113m}In-DTPA for assessing liquid-phase emptying in a dual-isotope solid/liquid gastric emptying study. 17 refs., 3 figs., 2 tabs.

• OSTI ID: 508544
• Journal Information: Journal of Nuclear Medicine, Vol. 36, Issue 3; Other Information: PBD: Mar 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GALLIUM 67
EVALUATION
COST
RETENTION
EXCRETION
AVAILABILITY
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
GASTROINTESTINAL TRACT
METABOLISM
SCINTISCANNING
TRACER TECHNIQUES
DIGESTIVE SYSTEM DISEASES
INDIUM 111
INDIUM 113
CITRATES
METABOLIC DISEASES
RATS
ELECTROPHORESIS