Distribution of. alpha. -aminoisobutyric acid in tissues of lean and genetically obese mice

Journal Article · Mon May 01 04:00:00 EDT 1989 · Proceedings of the Society for Experimental Biology and Medicine; (USA)

OSTI ID:5084599

Tews, J K; Harper, A E ^[1]

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1. Univ. of Wisconsin, Madison (USA)

Distribution of tracer amounts of the nonmetabolizable neutral amino acid {alpha}-(1-{sup 14}C)aminoisobutyric acid (AIB) between blood and several tissues was measured in lean and ob/ob mice over an 8-hr period. As AIB was injected on the basis of body weight and as ob/ob mice have a relatively low blood volume, absolute concentrations of AIB in blood and tissues were almost always higher in the obese than the lean mice. However, the ratio of AIB concentration in the tissues to that in the blood was clearly higher in skeletal muscle, diaphragm, and brain, and possibly higher in liver of the lean than of the obese animals. Ratios in heart were similar. The results suggest that lean and genetically obese mice differ in their capacity to transport amino acids between blood and various tissues.

• OSTI ID: 5084599
• Journal Information: Proceedings of the Society for Experimental Biology and Medicine; (USA), Journal Name: Proceedings of the Society for Experimental Biology and Medicine; (USA) Vol. 191:1; ISSN PSEBA; ISSN 0037-9727
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
GLANDS
HEART
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLIC DISEASES
MICE
MUSCLES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
WEIGHT