Biologically based epidemiological studies of electric power and cancer

Journal Article · Wed Dec 01 04:00:00 EST 1993 · Environmental Health Perspectives

DOI:https://doi.org/10.2307/3431665· OSTI ID:508364

Stevens, R G ^[1]

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1. Pacific Northwest Lab., Richland, WA (United States)

Use of electricity is a hallmark of the industrialization process, but there has been no suspicion that electricity could increase the risk of cancer. Recently, however, a number of epidemiologic studies have suggested that electromagnetic fields (EMF) may do just that. Although few cancer experiments have been done yet, there are a number of biological effects of EMF reported in the literature that might provide bases for designing cancer experiments and epidemiologic studies. These include effects of EMF on: (a) DNA transcription and translation, (b) calcium balance in cells, and (c) pineal production of melatonin. Alterations in DNA transcription and translation could have pleiotropic effects. Disruption of calcium homeostasis has many implications including oncogene activation, promotional activity via protein kinases and ornithine decarboxylase (ODC), and increasing oxidative stress. Reduction of melatonin suggests a possible increased risk of cancers of hormone-dependent tissues such as breast and prostate. The idea that a cancer-causing agent must either be an initiator or a promoter should be discarded; indeed, the phenomenologic meaning of these two terms has become confused with imputed mechanistic necessity in recent years. Agents that affect division of normal cells or of fully transformed cells can play an important role in clinical cancer development quite apart from initiation or promotion. Epidemiologic studies of EMF and cancer should attempt to take account of other products of electric power (e.g., light at night) or factors associated with occupational EMF exposure (e.g., toxic chemicals) that may increase cancer risk and therefore act as cofactors or confounders. Epidemiology and laboratory studies should act synergistically in determining if there is a problem and identifying mitigation strategies if needed. 84 refs., 3 figs., 1 tab.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 508364
• Journal Information: Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.4 Vol. 101; ISSN EVHPAZ; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

24 POWER TRANSMISSION AND DISTRIBUTION
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
CARCINOGENS
DNA
ELECTROMAGNETIC FIELDS
EPIDEMIOLOGY
HEALTH HAZARDS
MELATONIN
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORNITHINE
POWER TRANSMISSION LINES
PROSTATE
TRANSCRIPTION