Effects of exposure to factor concentrates containing donations from identified AIDS patients

Journal Article · Fri Oct 03 00:00:00 EDT 1986 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1986.03380130086033· OSTI ID:5073098

Jason, J; Holman, R C; Dixon, G; Lawrence, D N; Bozeman, L H; Chorba, T L; Tregillus, L; Evatt, B L

The authors recipients of eight lots of factors VII and IX voluntarily withdrawn from distribution because one donor was known to have subsequently developed the acquired immunodeficiency syndrome with a nonexposed cohort matched by age, sex, and factor use. The factor VIII recipient cohorts did not differ in prevalence of antibody to human immunodeficiency virus (HIV), T-cell subset numbers, T-helper to T-suppressor ratios, or immunogloubulin levels. Exposed individuals had higher levels of immune complexes by C1q binding and staphylococcal binding assays and lower responses to phytohemagglutinin and concanavalin A. However, only the staphylococcal binding assay values were outside the normal range for our laboratory. Factor IX recipient cohorts did not differ in HIV antibody prevalence or any immune tests. Although exposed and nonexposed individuals did not differ from each other in a clinically meaningful fashion at initial testing, both the exposed and nonexposed cohorts had high rats of HIV seroprevalence. Market withdrawals were clearly insufficient means of limiting the spread of HIV in hemophilic patients; however, the currently available methods of donor screening and viral inactivation of blood products will prevent continued exposed within this population.

• Research Organization: Centers for Disease Control, Atlanta, GA
• OSTI ID: 5073098
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Vol. 256:13
• Country of Publication: United States
• Language: English

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BLOOD
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INTERMEDIATE MASS NUCLEI
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550601* - Medicine- Unsealed Radionuclides in Diagnostics