Comparison of the doubly labeled water (2H2(18)O) method with indirect calorimetry and a nutrient-balance study for simultaneous determination of energy expenditure, water intake, and metabolizable energy intake in preterm infants

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5072951

Roberts, S B; Coward, W A; Schlingenseipen, K H; Nohria, V; Lucas, A

The doubly labeled water method was compared with indirect calorimetry and a nutrient-balance study for simultaneous determination of rates of CO/sub 2/ production, energy expenditure, and water intake over 5 days in four preterm infants. Additionally, metabolizable energy (ME) intake estimated using the isotope procedure (as energy expenditure plus an estimate for energy deposition based on weight gain), was compared to ME intake measured in the balance study. Compared to values obtained by traditional methods, calculated CO/sub 2/ production, energy expenditure, and water intake differed by -1.4 +/- 4.8% (SD), +0.3 +/- 2.6%, and +5.7 +/- 1.4%, respectively; the difference in water intake was significant (p less than 0.05). Calculated ME intakes were 5.3 +/- 19.3% less than measured intakes, but the difference was not significant. These findings indicate that the doubly labeled water method can provide accurate information on rates of CO/sub 2/ production, energy expenditure, and water intake in preterm infants, but individual estimates of ME intake may be subject to substantial error.

• Research Organization: Dunn Nutrition Unit, Cambridge, England
• OSTI ID: 5072951
• Journal Information: Am. J. Clin. Nutr.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INFANTS
BODY FLUIDS
WATER
DOUBLE LABELLING
BODY COMPOSITION
CALORIMETRY
CARBON DIOXIDE
HEAVY WATER
MATHEMATICS
MEASURING METHODS
NUTRIENTS
OXYGEN 18
TRITIUM OXIDES
AGE GROUPS
BIOLOGICAL MATERIALS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CHILDREN
EVEN-EVEN NUCLEI
HYDROGEN COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MATERIALS
NUCLEI
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
STABLE ISOTOPES
TRITIUM COMPOUNDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics