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Differential recovery of circulating T cell subsets after nodal irradiation for Hodgkin's disease

Journal Article · · J. Immunol.; (United States)
OSTI ID:5071937
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To better understand the immunologic effects of lymphoid irradiation (LI), blood levels of T cell subsets were sequentially monitored in 15 patients before, during, and after irradiation treatment for Hodgkin's disease. Blood levels of all lymphocytes, T cells, and T cell subsets (defined by OKT4 and OKT8) fell dramatically and in similar proportions during early therapy, reaching levels less than 20 to 25% of control by the completion of mantle irradiation, and continuing at very depressed levels through the completion of therapy. Blood levels through the completion of therapy. Blood levels of OKT8-reactive (OKT8/sup +/) cells returned to pretreatment levels between 6 to 8 mo after LI, whereas blood levels of OKT4-reactive (OKT4/sup +/) cells returned to only 42% of previous values over the same period. During the recovery period, discrepancies of 208 +/- 32 cells/mm/sup 3/ (3 to 5 months post LI) and 198 +/- 32 cells/mm/sup 3/ (6 to 8 mo post LI) developed between the blood levels of OKT3/sup +/ cells and the sum of OKT4/sup +/ and OKY8/sup +/ cells. This suggests the emergence of OKT4/sup +//OKT3/sup -/, OKT8/sup +//OKT3/sup -/, and/or OKT4/sup +//OKT8/sup +/ cells. The authors concluded that LI is similarly cytotoxic to peripheral blood T cell subpopulations. The reversed ratio after LI is a result of a slower repopulation of the peripheral blood by OKT4/sup +/ cells relative to OKT8/sup +/ cells. T cells after LI show a high degree of antigenic immaturity. It is postulated that the bone marrow that lies outside the fields of treatment and contains predominantly immature OKT8/sup +//OKT3/sup -/ cells is a major source of T cells repopulating the peripheral blood after LI.

Research Organization:
General Hospital, Boston, MA
OSTI ID:
5071937
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 132:2; ISSN JOIMA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
HEMIC DISEASES
HODGKINS DISEASE
IRRADIATION
LEUKOCYTES
LEUKOPENIA
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOMAS
LYMPHOPENIA
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PARTIAL BODY IRRADIATION
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECOVERY
SIDE EFFECTS
SOMATIC CELLS
THERAPY