High-dose MR in the evaluation of brain metastases: Will increased detection decrease costs?

Journal Article · Wed Jun 01 04:00:00 EDT 1994 · AJNR. American Journal of Neuroradiology

OSTI ID:50619

Black, W C ^[1]

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1. Dartmouth-Hitchcock Medical Center, Lebanon, NH (United States)

Brain metastases occur in about 25% of patients with cancer and are often diagnosed within the first year after the diagnosis of the primary tumor. The treatment of patients with brain metastases usually depends on whether they are solitary or multiple. Surgical resection has been shown to prolong survival by 6 months and improve the quality of life in patients with solitary brain metastases. However, surgery is not usually considered appropriate for patients with multiple brain metastases. A phase III multicenter trial in this issue demonstrates that the sensitivity of magnetic resonance (MR) in the detection of brain metastases can be increased by increasing the dose of contrast. In this trial comparing high-dose (0.3 mmol/kg) with standard-dose (0.1 mmol/kg) gadolinium, 50% more lesions were detected on the high-dose examinations. 15 refs., 1 tab.

• OSTI ID: 50619
• Journal Information: AJNR. American Journal of Neuroradiology, Journal Name: AJNR. American Journal of Neuroradiology Journal Issue: 6 Vol. 15; ISSN 0195-6108; ISSN AAJNDL
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BRAIN
CONTRAST MEDIA
COST BENEFIT ANALYSIS
DETECTION
DIAGNOSTIC USES
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
MAGNETIC RESONANCE
METASTASES
NERVOUS SYSTEM DISEASES