Sizes and distributions of intrinsic neurons incorporating tritiated GABA in monkey sensory-motor cortex
Journal Article
·
· J. Neurosci.; (United States)
OSTI ID:5053690
Neurons accumulating (3H)gamma-aminobutyric acid (GABA) were identified autoradiographically in frozen and plastic sections after injection of the material in the monkey somatic sensory (areas 3, 1, and 2), motor (area 4), and parietal (area 5) cortex following intravenous administration of a GABA transaminase inhibitor, amino-oxyacetic acid. Two general forms of labeled cells are recognized: those with large diameter (15- to 20-micrometer) somata, probably corresponding to the basket cells of Golgi studies, and those with small diameter (6- to 12-micrometer) somata, probably corresponding to several other types. The sizes and laminar distributions of labeled cells in the cytoarchitectonic fields of the first somatic sensory are (SI) are similar. In these areas, the greatest concentrations of labeled cells are in layer II, in layer IV, and in the superficial stratum of layer IV. In area 5, there are many fewer labeled cells in layer IV. In area 4, the labeled cells are larger and distributed more homogeneously, though there are fewer in layer VI. The large labeled cell type is concentrated in layers III and V of all areas. The smaller labeled types are found in all other layers, including layer I. In layer IV, they form approximately 40% of the total small-celled neuronal population.
- OSTI ID:
- 5053690
- Journal Information:
- J. Neurosci.; (United States), Journal Name: J. Neurosci.; (United States) Vol. 1:4; ISSN JNRSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
550801 -- Morphology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DRUGS
ENZYME INHIBITORS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
MORPHOLOGY
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PRIMATES
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
550801 -- Morphology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DRUGS
ENZYME INHIBITORS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
MORPHOLOGY
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PRIMATES
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES